25/03/2026 - New paper on T-cell activation models
A number of T-cell activation models have been proposed to describe how antigens trigger an immune response.
To analyse their identifiability, observability and sensitivity, it is necessary to have formulas relating their measurable outputs to model parameters.
In this paper we derive such formulas for models for which they were yet unknown, thus enabling their exploitation to understand and control the immune response.
The paper, written by Xabier and Alejandro in collaboration with Jose Faro, can be read here.
13/03/2026 - New release of STRIKE-GOLDD
We have added a new algorithm to our STRIKE-GOLDD toolbox.
Called 'SIM_PDE', it searches for scaling symmetries that lead to unidentifiability and/or unobservability in PDE models.
It has been implemented by Mahmoud.
The new release also contains minor improvements, such as fixing a number of bugs.
01/12/2025 - New paper on accessibility and observability analysis
Mahmoud's first paper, "Assessment of Computational Tools for Analysing the Observability and Accessibility of Nonlinear Models", has just been published
in Computation. Check it out here.
Co-written by Adriana and Alejandro, it provides a systematic comparison of two MATLAB tools, StrucID and STRIKE-GOLDD.
It features research carried out in the DYNAMO-bio project.
26-29/11/2025 - Visit to Stavanger
This week, Alex was in Stavanger to serve in the evaluation committee of Eivind Haus' PhD defence.
Eivind's thesis, "Identifiability and parameter estimation in models of biomolecular systems", was supervised by Kristian Thorsen and Tormod Drengstig at the University of Stavanger.
An excellent work, carried out in a research group that has many similarities with BICO!
04/11/2025 - New paper on accessibility and input observability
Our new paper, "On the relation between the accessibility and input observability tests in ODE systems", has just been published
in Systems Science & Control Engineering. It is the result of a collaboration with Manolis Chatzis and its origins date back to Sandra's visit to his group in Oxford in 2023.
You can read it (Open Access) here.
06/10/2025 - Special issue of Current Opinion in Systems Biology
Alejandro and Mat Simpson (Queensland University of Technology, Australia) have served as guest editors of a special issue of Current Opinion in Systems Biology.
It features 9 papers on “Identifiability, estimation and uncertainty in mathematical modelling”, written by some of the leading experts in the field.
It can be accessed here.
30/09/2025 - New paper on cancer modelling
Adriana's first paper, "Analysing the Structural Identifiability and Observability of Mechanistic Models of Tumour Growth", has just been published
in Bioengineering. Check it out here.
Co-written by Alejandro, it provides an overview of 20 published model of tumour growth under different treatments.
It features research carried out in the DYNAMO-bio project.
26/09/2025 - Participation in the G Night
Adriana and Sandra took part in the G-Night, a scientific dissemination activity for kids organized by the Universidade de Vigo.
They showcased the application of our work to the simulation of glucose-insulin regulation.
More details here.
26/09/2025 - Open Invited track at IFAC WC
We are co-organizing an Open Invited Track at the IFAC World Congress 2026, which will be held in Busan, South Korea.
It is called "Challenges in Computational Systems Biology",
and the paper submission deadline is November 26.
